Leading Chitosan Manufacturer

Science, innovation, and sustainability find an intersection in the world of biopolymers—few substances exemplify this synergy better than chitosan. Crafted with vision and precision, Bio21 stands as a recognized chitosan manufacturer and leader in the manufacture of chitosan at industrial scales, finely tuned to suit the demands of modern markets. Drawing from over two decades of experience, Bio21 continues to drive progress, meeting the highest standards of quality and adaptability.

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The Chitosan Advantage: More Than Just a Biopolymer

Chitosan, a derivative of chitin sourced primarily from seafood byproducts like snow crab, shrimp shells, and squid pens, holds a unique place in numerous industries. Its appeal lies in its remarkable versatility, biocompatibility, and the end product's ability to blend gently into both food and pharmaceutical environments.

What sets chitosan apart is its eco-conscious origin story. Instead of relegating shellfish waste to landfills, it transforms it into a valuable, functional material with a wide array of uses. Each batch begins with clean, freshly sourced shells—many from snow crabs—carefully selected from certified GMP/HACCP food processing lines. This sourcing is critical: clean raw materials form the foundation of a biopolymer that is pure enough even for pharmaceutical applications.

Chitosan serves as an agent of positive change, finding its way into:

Dietary supplements, bonding triglycerides and supporting LDL cholesterol management
Functional food ingredients, where fiber enrichment and texture modifications are prized
Medical devices, wound care products, and drug delivery systems, thanks to its biocompatibility

Precision in Every Specification

Bio21 continually pushes the boundaries of what chitosan can offer. Their approach goes far beyond the basics—each product is tailored for precise industrial needs, with parameters meticulously controlled for deacetylation degree, molecular weight, and viscosity.

Key product features include:

Specification	Range	Application Highlights
Deacetylation Degree (%)	Less than 80 80-90 more than 90	Determines solubility, charge density, and application suitability
Molecular Weight (kDa)	10 – 2000	Influences viscosity, film strength, and bioactivity
Viscosity @1.0% solution(cPs)	5 – 4000	Impacts gelling, thickening, and formulation characteristics
Source Materials	Blue/Alaska crab shells, squid pen, shrimp shells	Customization for food, supplement, and pharmaceutical markets

Meticulous calibration of these properties enables the chitosan to align with exact industry requirements. Whether a lightweight, low-viscosity powder for capsule manufacturing or a robust, high-viscosity grade for edible food films, Bio21 is equipped to deliver consistency at any scale.

Reliability at Industrial Scale

Few manufacturers maintain the consistency and resiliency needed to supply chitosan in true industrial quantities. Bio21’s annual capacity—hovering between 60-100 metric tons—reflects not simply scale, but robust logistics and a commitment to quality at every stage.

Multiple layers of certification reassure partners across numerous regions: adherence to QMS protocols, GMP/HACCP food safety systems, EU compliance, and ever-present attention to traceability. This builds a foundation of trust, critically important when chitosan is bound for high-stakes applications like food enrichment and medical formulations.

As a chitosan manufacturer, Bio21’s team recognizes that stable supply is just one part of the equation. Their operations reflect:

A reliable partner network at the raw material phase, ensuring only premium shells are used
Stringent batch-to-batch quality checks and traceability from shell to shelf
Investment in sustainable, waste-conscious sourcing that aligns with both regulatory and corporate responsibility standards

Meeting Tomorrow’s Needs

Innovation seldom stands still. Bio21's R&D programs routinely lead to new formulations, advanced blends, and chitosan derivatives designed to address niche demands. Their Blended-Chitosan L112 Biopolymer represents just one frontier—an expertly-balanced fusion of active ingredients and proprietary blends, perfect for supplement and pharmaceutical partners aiming to amplify health impacts.

The company’s product development philosophy focuses on both purity and performance. This means chitosan grades manufactured by Bio21 are not just versatile, but also robust enough to withstand the unique rigors of specific end uses.

Specialty Chitosan Lines

Pharmaceutical and Food-Grade Chitosan — Ultra-purified for use in dietary supplements, capsules, and even medical devices.
Chitosan for Dietary Use — Tailored to effectively bind fats and promote digestive health as a functional food or supplement ingredient.
Blended-Chitosan L112 Biopolymer — Combining chitosan’s base properties with custom actives or excipients for unique, value-added final products.
Chitosan material — We Tailor Chitosan to Meet Demands,we are specialists in customizing Chitosan specs in Molecular Weight / Viscosity and Degree of Deacetylation (%DD) variances according to the client's requirements

These lines reflect a keen awareness of global trends: an increasing demand for transparent sourcing, plant-based alternatives, and eco-friendly production.

Why Chitosan, and Why Now?

Environmental responsibility steers the culture at Bio21. The chitosan manufacturing process at Bio21 is grounded in the conviction that valuable resources should not go to waste. Snow crab shells, once considered merely a disposal issue, have become a vital source for high-quality biopolymers.

Production begins with raw materials that meet the strictest regulatory criteria. Close partnering with certified food processing factories underpins both traceability and sustainability—ensuring that every batch is not only safe, but also ethically produced. Sourcing from EU and HACCP-certified lines builds confidence in both safety and environmental stewardship.

This is chitosan’s quiet revolution: sustainable, scalable, and with the power to change how industries utilize resources.

Twenty Years: A Track Record of Excellence

Success in industrial manufacturing, particularly as a leading chitosan manufacturer, is measured both by scale and by consistency over time. Bio21’s twenty-year history in chitosan production provides an assurance that newer entrants cannot match. Institutional know-how, continuous technological upgrades, and attention to detail allow the company to anticipate shifts in demand and regulatory landscapes.

A few distinguishing characteristics include:

Decades-long R&D investment in optimizing deacetylation, purification, and blending processes
A focus on customer collaboration, adapting specifications as needed to support next-generation product development
Proactive compliance that keeps clients protected from regulatory risk

Quality systems are not an afterthought. Bio21 integrates best practices from QMS, GMP, and HACCP frameworks at every production stage, combined with rigorous EU certification standards for food safety and export readiness.

The Bio21 Difference: From Sea to Science

At each turnaround, Bio21’s chitosan solutions reflect deep care for quality, sustainability, and adaptability. The company’s close involvement in raw material sourcing, from the moment shells are discarded on the production line, through clean GMP/HACCP-certified processing, sets the stage for purity and performance.

What comes out at the end is more than just a commodity or ingredient; it's a testament to using science responsibly and resourcefully. Chitosan from Bio21 is purpose-built for health, safety, and success, meeting the needs of partners who demand only the best.

Industrial buyers, product formulators, and developers have in Bio21 a partner ready to set new standards—consistently, confidently, and with a vision toward a more resourceful future.

The Drive to Innovate: Our Story

Bringing the story of chitosan into the modern industrial fold requires more than technical know-how. It takes vision, grit, and genuine belief in the potential of science to do good for all life.

Our beginnings were humble—a small team with a background in chemical technology, operations research, and biology. The early days demanded patience and perseverance. Scaling up from lab-scale processes to industrial outputs involved trial, error, and endless hours in pilot plants. Yet, our passion grew stronger with each setback overcome.

Our founders drew on their academic backgrounds, blending chemistry, operations research, and bioengineering. As we grew, we committed not just to chitosan, but to sustainable sourcing, rigorous research and development, and high-quality standards.

Mr. Kasem Pansanga
B.Sc Operations Research. Oct. 1991
Ramkhamhaeng University

Mr. Paisan Pansanga
M.Sc Chemical Technology. Oct. 1998
Chulalongkorn University

April 2001

Decades ago, a small group of passionate scientists and entrepreneurs sparked a revolution in sustainable materials by focusing on chitosan—a substance with untapped potential sourced from the shells of crustaceans. Their company, Aqua Premier company limited, and then BIO21 company limited, were born out of the conviction that human ingenuity, scientific knowledge, and an ongoing commitment to environmental wellness could create valuable solutions not only for people, but for the broader complex web of life.

This vision was not a mere business strategy; it represented a belief that the role of a manufacturer extends far beyond supplying raw materials. It’s a commitment to stewardship, innovation, and inspiring change on a scale that weaves together chemistry, biotechnology, and thoughtful resource management.